QurAlis is developing therapeutics to treat Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, a progressive neurodegenerative disease impacting nerve cells in the brain and spinal cord. In ALS, nerve cells degenerate, reducing muscle function and causing loss of muscle control. ALS can be traced to mutations in over 25 different genes and is often caused by a combination of multiple sub-forms of the condition. As the average life expectancy of this terminal disease is three years and there is currently no cure, treatments developed by QurAlis have the potential to provide relief to the more than 200,000 people suffering from ALS worldwide.
AmbAgon Therapeutics develops first-in-class small-molecule therapeutics for cancer by augmenting the tumor-suppressing functions of the 14-3-3 protein, a truly novel approach for inhibiting oncogenic transcription factors for cancers with defined drivers, such as breast cancer. AmbAgon combines unique expertise in 14-3-3 drug discovery towards previously undruggable targets with a broad platform technology and industry experience to discover the next generation of anticancer therapies.
Switch Therapeutics is a venture backed startup company developing a new generation of RNAi therapies based on revolutionary technology developed at Caltech, City of Hope and Harvard Medical School.
Thrive is a consumer well-being and productivity platform that offers science-based solutions to address the workplace stress epidemic and improve performance. The annual cost of US workplace stress is $300B. 75-90% of healthcare costs are preventable and lifestyle-based. Current approaches to behavior change aren’t working. Led by CEO Arianna Huffington, Thrive is building science based products and content that change behavior, enhancing well-being, performance, purpose, and creating healthier relationships with technology.
High growth mobile banking platform currently serving 8 million account holders.
Carbon Robotics has created a low-cost collaborative robot to replace humans on repetitive production lines.
At Shef, we are bringing the sharing economy to the table. We believe in providing our Shefs (at-home parents, retirees, those lacking technical skills, and those who simply love to cook!) the opportunity to make an income from their very own kitchen. We also believe that every person should have access to a healthy, home-cooked meal at a fraction of the prices charged.
Dren Bio reprograms natural killer cells to attack cancer cells by leveraging the antibody-dependent cellular cytotoxicity process that natively exists in human bodies.
Digital News Platform that represents communities which have been historically and continuously left out of the conversation and the history books.
builds studio apartments in homeowners’ backyards, which are then rented out for income.
Vedere is an emerging biotechnology company focused on developing best-in-class genotype-agnostic gene therapies for vision restoration. Based initially on the ground-breaking work of its scientific co-founders, John Flannery and Ehud Isacoff at UC Berkeley. Vedere is developing optogenetic gene therapies to treat a broad range of inherited retinal regenerative disorders.
Degenerative diseases of the retina are amongst the most prevalent category of genetic diseases and age-related macular degeneration (AMD) is estimated to affect nearly 200 million people worldwide. The high prevalence of these disorders is due to the extreme sensitivity of retinal cells to physiological or genetic perturbation. While substantial progress has been made in the treatment of a subset of these patients, as shown by the success of gene therapies for the 3500 patients in the US and EU with RPE65 mutations or the roughly 10 percent AMD patients with a specific anti-VEGF antibodies disease type, many patients are still left without any efficacious treatment options. Vedere’s therapies hold the promise to treat a wide range of retinal degenerative diseases and yield improved visual perception.
Persona Biome is a microbiome dermatology platform that provides custom microbial ferments direct to consumer for cosmetic use. Persona utilizes a digital platform that monitors consumer’s response to different ferments to identify the product that is most beneficial to the individual consumer while minimizing potential ethical risks related to consumer information and product safety.
Mammoth Biosciences is a CRISPR-based platform for disease detection. Mammoth develops low-cost DNA tests that have the potential to make medical diagnostics more accessible and affordable allowing physicians to more quickly and comprehensively diagnose and treat disease.
BlocPower is a Brooklyn-based energy technology startup rapidly greening American cities. Since its founding in 2012, the company has completed energy projects in nearly 1,000 buildings and delivers results ahead of schedule and under budget. BlocPower utilizes its proprietary software for analysis, leasing, project management, and monitoring of urban clean energy projects and its customers are saving 20-40% on their energy bills each year. The company is backed by the world’s top investors, including Kapor Capital, one of Uber’s first investors, Andressen Horowitz, early investor in Facebook, Twitter, AirBnB and Lyft, and the former Chairman of Google.
NUGGS are made with innovative protein technologies enabling us to create a tender and meteor nugget that is more advanced than an animal-based nugget. NUGGS 1.4 contains 25g of protein (about 2.5x more than animal-based), 1.5g of fat (80% less than animal-based) and are also cholesterol free.
Reality Defender is intelligent software built to run alongside digital experiences (such as browsing the web) to detect potentially fake media. Similar to virus protection, it scans every image, video, and other media that a user encounters for known fakes, allows reporting of suspected fakes, and runs new media through various AI-driven analysis techniques to detect signs of alteration or artificial generation. At the core of our social responsibility efforts is a nonprofit established to anticipate and counteract the dangers of AI by giving all of us the tools to protect our lives, prosperity, dignity and human agency. We spend considerable resources and energy thinking through, and educating the public about the risks of AI, especially those that could potentially destabilize human societies or prevent us from enjoying the vast benefits of the advancement of AI.
Our gun detection system connects directly to your current security camera system to deliver fast, accurate threat detection – including guns, knives, and aggressive action. Our system can also alert you to falls, accidents, and unwelcome visitors. Athena Security provides never before used proactive threat detections such as gun detection before a active shooter uses a weapon, knife detection before a villian tries to hurt someone.
Novel solutions for Chronic Lung Disease
ScholarMe helps students apply for scholarships, FAFSA®, student loans, income share agreements (ISAs) and every other source of college funding.
Juno is a technical University of the future.
Emi Labs is developing a virtual assistant for human resources workers that automates the hiring process for low-skilled jobs.
Halo is an end to end VR/AR prototyping and design platform for neuroscience. Halo Sport is a brain stimulator that helps develop muscle memory faster by applying a small electric current to the area of the brain that controls movement, putting it into a state of hyperlearning.
NexGenT is disrupting engineering education by leveraging cutting edge technologies
Fitspot is a tech-enabled, turnkey, central hub of wellness services for corporate property owners (e.g., personal fitness, wellness coaching, health screening). FitSpot is an integrated fitness and wellness services provider for corporate real-estate enterprises and property owners, with a simple, flexible way to deliver wellness services and clear path to monetization within massive customer budgets.
Developing robots that care for people.
Blue Note Therapeutics leverages cutting-edge digital technology and neuroscience to commercialize prescription digital therapeutics for the treatment of serious medical conditions.
Cadence is developing a next generation read/write brain computer interface (BCI) platform technology. The company’s breakthrough hardware and software system reads neural signals directly from the cortical surface of the brain and also writes back into the brain using novel brain mapping algorithms and precisely focused and individualized electrical signals. This closed-loop neuromodulation technology is being deployed to treat drug-resistant epilepsy and other brain-related conditions. Core technology in-licensing and development partnerships are in place. Epilepsy is one of the most prevalent and debilitating neurological disorders, which manifests as sudden, unexpected seizures that can significantly limit human potential. Current pharmacological and surgical approaches to epilepsy are inadequate for many patients with the disorder. Cadence’s technology will allow people with epilepsy and other neurological conditions to reduce the severity of their conditions and in many cases return to normal lives.
Kami is developing AI-based personalities with a distinctly human voice interface, that engage in conversation and have the full emotional spectrums, moods and temperaments of actual people.
Developer of an AI-powered chatbot designed to deliver cognitive behavior therapy at scale. The company’s mental health assessment chatbot offers therapy and emotional support for mental illnesses such as depression and anxiety disorders through natural, personalized and human-like conversations so as to help people monitor and regulate their mood, enabling young adults to decrease symptoms of depression and anxiety and improve their emotional quotient.
Swing is a stealth mode prescription digital therapeutics company for rheumatologic diseases, fully incubated by JAZZ. Rheumatologic diseases – including osteoarthritis, psoriasis, fibromyalgia, and rheumatoid arthritis – are highly prevalent and debilitating, leading to $30B+ in annual drug spend, significant healthcare utilization, and lost productivity.
Resolving drug resistance in cancer and bacteria.
Biobot Analytics analyzes city sewage to estimate opioid consumption.
Glycomine is targeting orphan disorders of glycosylation (sugar-coating of proteins). Remarkably, 50% of all proteins in our bodies are glycosylated. Attachment of specific sugars to the surface of proteins is required for correct protein folding and/or stabilization, dictates the adhesion and migration pattern of various immune cells, and controls the solubility and activity (protein-protein binding) of many enzymes. Patients with deficiencies in glycosylation have devastating and life-threatening disease with no therapeutic options. Glycomine is developing a means of delivering a sugar intermediate to cells that helps restore normal glycosylation in pre-clinical studies.
Glycomine’s lead program seeks to provide treatment for Congenital Disorder of Glycosylation Type Ia(CDG). This disorder is severely debilitating and life-threating. Approximately 20% of suffers do not survive the first 5 years of life due to multiple organ failure. Living patients exhibit hypotonia (low muscle tone), failure to thrive, hepathopathy (liver disease), coagulopathy (bleeding and abnormal clotting), and chronic diarrhea and infections. Glycomine’s drug development program holds the promise to provide the first therapies for patients and caregivers struggling with CDG.
Walker & Company’s purpose is to make health and beauty simple for people of color.
Wild Earth is challenging the status quo of pet food with clean protein made without animal ingredients.
A social impact company. The first to bring precision medicine, used in humans, to animals with cancer.
Carta helps hospitals and health care providers use data to optimize operations. AI helps drive operational improvements leveraging existing EMR data. Carta allows for better patient-centric care decisions with minimal change to existing infrastructure or workflows.
Prostate cancer is a significant burden for men, with about 160,000 new cases diagnosed each year in the US and affecting 1 in 6 men in their lifetimes. Current options to manage early-stage prostate cancer include either active surveillance (regular exams and biopsies) or immediate, whole-gland prostatectomy or radiation therapy. Immediate treatment can be curative for low-to-intermediate risk prostate cancer but exposes men to considerable risk of impotence and incontinence. Active surveillance is the least burdensome option but presents a risk of clinical progression and metastasis. There is a lack of an intermediate alternative that can reduce risk of disease progression but with fewer side effects than the existing treatment options. Alessa Therapeutics is developing a treatment that fills this large gap in current prostate cancer treatment options. Alessa’s product is an implantable, silicone-based device that delivers anti-androgen drugs locally to the prostate tissue. Implantation of the device is expected to be concurrent with routine biopsy of men diagnosed with prostate cancer and use a similar biopsy needle to insert the device. Alessa has shown sustained release of bicalutamide (an anti- androgen given systemically to treat prostate cancer) in vitro and conducted in vivo studies in mice to show efficacy and in dogs to show tissue specificity.
Telo is developing therapeutics for a wide range of tumors based on their discovery of the mechanism that drives the oncogenic function of TERT promoter mutations. The novel mechanism holds the promise that inhibition of cell proliferation can be targeted only to active cancer cells. Telo’s first indication will be TERT promotor mutant glioblastoma which represents ~83% of all glioblastoma tumors.
Alpine Roads is unlocking the power of plants to create the next generation of animal-based food substitutes. Alpine Roads has engineered soybeans to express casein, the milk protein used to make cheese, and is now setting its sights on scalable mass-production.
Simple Health believes all women deserve access to birth control. They prescribe it online and deliver it free—no doctor or pharmacy visits required.
Kuli Kuli is America’s leading moringa brand providing the highest quality and most nutritious moringa available.
Joylux creates innovative health solutions targeting the enormous, but underserved female intimate care market. Joylux’s mission is to empower women to live their best lives.
Huckleberry is a next generation small business insurance platform on a mission to give small business owners back time. Over the last decade, software has replaced most paper-based business management systems – from accounting, to tax preparation, to payments. But commercial insurance is still bought and managed almost entirely offline, in a process that can involve layers of bureaucracy and take weeks to complete.
Sandstone is an innovative technology and healthcare start-up company producing medical products and research tools designed to improve healthcare by bringing the point of care closer to the patient, increasing access, reducing costs, improving sample preparation, and enhancing performance of bodily fluid analyses including blood and semen. Sandstone specializes in innovation that reduces the size and power requirements for applying centrifugal force to separate, stabilize, and analyze clinical samples. Advancements in microfluidics and mesofluidics work hand in hand with the centrifuge innovation to create CentriFluidics™.
Tivic Health Systems Inc. is a bioelectronic device company dedicated to developing microcurrent therapy solutions for chronic diseases and conditions. Founded in 2016, Tivic Health is part of a $6.2B global neuromodulation industry and is dedicated to harnessing the power of neuromodulation for home use products, empowering people to improve their health and quality of life. Products are grounded in science, clinically-proven, and FDA approved.
Scanwell Health aims to make proactive healthcare accessible for everyone. Their first product allows customers to find out if they have a UTI in three minutes from an at-home test and get a same-day prescription if needed. Additional urinalysis direct-to-consumer tests are under development, including testing for Kidney Disease.
Quit Genius is a gamified behavioural therapy app to help smokers quit.
Wisdo connects people with shared life experiences and aggregates the world’s wisdom.
Pear discovers, develops, and commercializes Prescription Digital Therapeutics to treat diseases with high unmet need.
Mahana Therapeutics joins technology and healthcare expertise to produce innovative and cutting-edge digital therapeutics products.
Limbix develops technologies to enhance human performance across the spectrum from helping with disabilities to unlocking new capabilities. Limbix’s virtual reality experiences treat a wide range of mental health conditions and optimize brain health.
Persephone Biome is trying to retune the gut microbiome to help cancer drugs work.
Level Ex is a medical technology company creating professional video games for physicians to advance decision-making skills.
Tells inspiring stories of pioneers who are hard at work changing the world and making a difference. Each week, videos are released featuring passionate innovators who are solving humanity’s biggest challenges by thinking differently.
C16 Bioscience uses synthetic biology to produce a sustainable alternative to palm oil.
Aspire lets small businesses register for a line of credit in less than 5 minutes and get a same day credit assessment.
Akili builds clinically-validated cognitive therapeutics, assessments, and diagnostics that look and feel like video games.
Online prescriptions for UTIs, birth control, acne and more.
Aira develops assistive technology that connects the blind with a network of certified agents via wearable smart glasses.
Citizen’s mission is to keep people safe and informed. Citizen believes everyone has the right to know what’s happening inside their communities in real time, and that transparency can drive change for the better. Citizen users are empowering the city of the future, building new ways to bring people together, creating a safer world, and democratizing 911.
70 Million Jobs is the first for-profit employment job board for people with criminal records. Helping the formerly incarcerated re enter the workforce as productive members of society.
Market place for doctors to find short term work at hospitals
Assists people who have learned to code get jobs.
K-8 Micro schools.
Helping on demand companies in India hire workers using WhatsApp.
Financing college education through ISAs
The impossible foods of dairy products